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Angiogenin (108-123)

Names

[ CAS No. ]:
112173-48-5

[ Name ]:
Angiogenin (108-123)

[Synonym ]:
angiogenin fragment 108-123
glu-asn-gly-leu-pro-val-his-leu-asp-gln-ser-ile-phe-arg-arg-pro
angiogenin (108-123)
h-glu-asn-gly-leu-pro-val-his-leu-asp-gln-ser-ile-phe-arg-arg-pro-oh

Biological Activity

[Description]:

Angiogenin Fragment (108-123) is a C-terminal segment 108-123 of Angiogenin that inhibits the enzymatic and biological activities of Angiogenin[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

Angiogenin Fragment (108-123) inhibits the initial rate of degradation of tRNA catalyzed by angiogenin in a concentration dependent manner yielding an apparent Ki value of 278 μM. Angiogenin Fragment (108-123) also inhibits nuclease activity of angiogenin when tRNA is the substrate. Furthermore, Angiogenin Fragment (108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay[1].

[References]

[1]. S M Rybak, et al. C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin. Biochem Biophys Res Commun. 1989 Jul 14;162(1):535-43.  

Chemical & Physical Properties

[ Molecular Formula ]:
C83H132N26O24

[ Molecular Weight ]:
1878.10000

[ Exact Mass ]:
1876.99000

[ PSA ]:
815.73000

[ LogP ]:
1.75640

Related Compounds