CM398

Names

[ CAS No. ]:
1121931-70-1

[ Name ]:
CM398

Biological Activity

[Description]:

CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[References]

[1]. Intagliata S, et al. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. AAPS J. 2020;22(5):94. Published 2020 Jul 20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₉N₃O₃

[ Molecular Weight ]:
395.49

CM398

Names

Biological Activity

Chemical & Physical Properties

Related Compounds