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Prepro-Atrial Natriuretic Factor (56-92) (human) trifluoroacetate salt

Names

[ CAS No. ]:
112199-06-1

[ Name ]:
Prepro-Atrial Natriuretic Factor (56-92) (human) trifluoroacetate salt

[Synonym ]:
Benzamide, N-[3-[3-[(cyclopropylcarbonyl)amino]-7-isoquinolinyl]-4-methylphenyl]-4-[1-(dimethylamino)ethyl]-
N-(3-{3-[(Cyclopropylcarbonyl)amino]-7-isoquinolinyl}-4-methylphenyl)-4-[1-(dimethylamino)ethyl]benzamide

Biological Activity

[Description]:

Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a Guanylate Cyclase activator that enhances particulate Guanylate Cyclase activity in the renal membrane and renal unit[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[In Vitro]

Prepro-ANF (56-92), human (1 µM; 10 min) enhances particulate guanylate cyclase from 105,000 g whole kidney homogenates, renal cortical and medullary membranes, and in the isolated distal nephrons[1].

[References]

[1]. Vesely DL, et al. Human prepro atrial natriuretic factors 26-55, 56-92, and 104-123 increase renal guanylate cyclase activity. Biochem Biophys Res Commun. 1987 Feb 27;143(1):186-93.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
646.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H32N4O2

[ Molecular Weight ]:
492.611

[ Flash Point ]:
344.7±31.5 °C

[ Exact Mass ]:
492.252533

[ LogP ]:
4.78

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds