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20(R)-Ginsenoside Rh2

Names

[ CAS No. ]:
112246-15-8

[ Name ]:
20(R)-Ginsenoside Rh2

[Synonym ]:
(3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside
20(R)-Ginsenoside Rh2
20(R)-Ginsenoside-Rh2
b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl
Ginsenoside-Rh2
(R) Ginsenoside Rh2
(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside
20-(R)-Ginsenoside Rh2
β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl
20(R)-GINSENOSIDERH2
Ginsenoside Rh2, 20(R)-

Biological Activity

[Description]:

20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6.

[2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40.

[3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

Chemical & Physical Properties

[ Density]:
1.19

[ Boiling Point ]:
726.4±60.0 °C at 760 mmHg

[ Melting Point ]:
225 °C

[ Molecular Formula ]:
C36H62O8

[ Molecular Weight ]:
622.873

[ Flash Point ]:
393.1±32.9 °C

[ Exact Mass ]:
622.444458

[ PSA ]:
139.84000

[ LogP ]:
5.62

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.572

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds