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HE-2500

Names

[ CAS No. ]:
112859-71-9

[ Name ]:
HE-2500

[Synonym ]:
16-fluoro-5-androsten-17-one

Biological Activity

[Description]:

Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

Ki: 0.51 μM (G6PD)[3]


[In Vivo]

Fluasterone (0.2% and 0.3%; in diet for 39 days) 对糖尿病小鼠有抗高血糖作用[2]。 Fluasterone (200 μg/mouse; intradermal injection; once) 抑制 TPA 诱导的急性炎症和表皮增生作用[3]。 Animal Model: Male C57BL/KsJ db/db mice, diabetic model[2] Dosage: 0.2% and 0.3% Administration: In the diet for 39 days Result: Markedly reduced plasma glucose levels.

[References]

[1]. Schwartz AG, et al. Potential therapeutic use of dehydroepiandrosterone and structural analogs. Diabetes Technol Ther. 2001 Summer;3(2):221-4.  

[2]. Pashko LL, et al. Antihyperglycemic effect of dehydroepiandrosterone analogue 16 alpha-fluoro-5-androsten-17-one in diabetic mice. Diabetes. 1993 Aug;42(8):1105-8.  

[3]. Schwartz AG, et al. Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16alpha-fluoro-5-androsten-17-one and its reversal by NADPH liposomes. Cancer Lett. 2001 Jul 10;168(1):7-14.

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
382.5ºC at 760mmHg

[ Molecular Formula ]:
C19H27FO

[ Molecular Weight ]:
290.42

[ Flash Point ]:
207.3ºC

[ Exact Mass ]:
290.20500

[ PSA ]:
17.07000

[ LogP ]:
4.85640

[ Vapour Pressure ]:
4.7E-06mmHg at 25°C

[ Index of Refraction ]:
1.529

Related Compounds