Argipressin

Names

[ CAS No. ]:
113-79-1

[ Name ]:
Argipressin

[Synonym ]:
EINECS 204-035-4
MFCD00133939
Argipressine
[Arg8]-Vasopressin (AVP)
CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
Argipressin Acetate
Argipressin

Biological Activity

[Description]:

Argipressin binds to the V1-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. Sequence: CysTyrPheGlnAsnCysProArgGly-NH2(Disulfide bridge: Cys1-Cys6).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Peptides

[In Vitro]

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC50=5 nM)[1]. AVP-induced [Ca2+]i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca2+]i responses are 100 pM in non-neuronal cells in DRG culture[2].

[References]

[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.

[2]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₄₆H₆₅N₁₅O₁₂S₂

[ Molecular Weight ]:
1084.232

[ Flash Point ]:
113℃

[ Exact Mass ]:
1083.437866

[ PSA ]:
512.03000

[ LogP ]:
-5.99

[ Index of Refraction ]:
1.724

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332

[ Precautionary Statements ]:
P261

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response.

Elife 4 , (2015)

In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3' poly(A) tail of ...

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.

PLoS ONE 10 , e0128881, (2015)

Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for a...

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time.

Proc. Natl. Acad. Sci. U. S. A. 112 , E3920-9, (2015)

The mammalian suprachiasmatic nucleus (SCN) forms not only the master circadian clock but also a seasonal clock. This neural network of ∼10,000 circadian oscillators encodes season-dependent day-lengt...