Biotin-PEG5-amine

Names

[ Name ]:
Biotin-PEG5-amine

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(17-amino-3,6,9,12,15-pentaoxaheptadec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
N-(17-Amino-3,6,9,12,15-pentaoxaheptadec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Biological Activity

[Description]:

Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
744.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₄₂N₄O₇S

[ Molecular Weight ]:
506.656

[ Flash Point ]:
403.9±32.9 °C

[ Exact Mass ]:
506.277405

[ LogP ]:
-2.50

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.510

Biotin-PEG5-amine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds