3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXIMIDAMIDE

Names

[ Name ]:
3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXIMIDAMIDE

[Synonym ]:
3,4-Dihydroisoquinoline-2(1H)-carboxiMidaMide
EINECS 214-470-1
3,4-Dihydro-2(1H)-isochinolin-carboxamidin
3,4-dihydro-1H-isoquinoline-2-carboximidic acid amide
3,4-Dihydro-2(1H)-isoquinolinecarboximidamide
Debrisoquin
Debrisochin
1,2,3,4-Tetrahydroisochinolin-N-carboxamidin
3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXAMIDINE
Isocaramidine
3,4-Dihydro-2(1H)-isoquinolinecarbimidamide
3,4-dihydro-1H-isoquinoline-2-carboximidamide

Biological Activity

[Description]:

Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

Human Endogenous Metabolite

[References]

[1]. Amanda L. Peiffer, et.al.TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.ACS Medicinal Chemistry Letters 2023 14 (6), 860-866.

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
309.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₃N₃

[ Molecular Weight ]:
175.23

[ Flash Point ]:
141.1ºC

[ Exact Mass ]:
175.11100

[ PSA ]:
53.11000

[ LogP ]:
1.67610

[ Vapour Pressure ]:
0.000626mmHg at 25°C

[ Index of Refraction ]:
1.649

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%