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NSC 228155

Names

[ CAS No. ]:
113104-25-9

[ Name ]:
NSC 228155

[Synonym ]:
4-Nitro-7-[(1-oxido-2-pyridinyl)sulfanyl]-2,1,3-benzoxadiazole
2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-

Biological Activity

[Description]:

NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

IC50: 0.36 μM (KIX-KID)[1]


[In Vitro]

NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with an IC50 of 2.09 and 6.14 μM, respectively[1].

[References]

[1]. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
627.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H6N4O4S

[ Molecular Weight ]:
290.255

[ Flash Point ]:
333.2±34.3 °C

[ Exact Mass ]:
290.010986

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.793

[ Storage condition ]:
-20℃

Related Compounds