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5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Names

[ CAS No. ]:
1133819-87-0

[ Name ]:
5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

[Synonym ]:
5-{4-[2-(3-Methoxyphenyl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione
UNII:81MXZ6QOBM
unii-81mxz6qobm
msdc-0602
2,4-Thiazolidinedione, 5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-
5-(4-(2-(3-METHOXYPHENYL)-2-OXOETHOXY)BENZYL)THIAZOLIDINE-2,4-DIONE

Biological Activity

[Description]:

MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism
Research Areas >> Metabolic Disease

[References]

[1]. Chen Z, et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48.

[2]. Vigueira PA, et al. The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017 Aug 1;102(8):985-999.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
608.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17NO5S

[ Molecular Weight ]:
371.41

[ Flash Point ]:
321.6±27.3 °C

[ Exact Mass ]:
371.082733

[ PSA ]:
110.49000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20℃

Related Compounds