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Bromo-PEG1-CH2COOH

Names

[ CAS No. ]:
1135131-50-8

[ Name ]:
Bromo-PEG1-CH2COOH

[Synonym ]:
MFCD20637665
Acetic acid, 2-(2-bromoethoxy)-
(2-Bromoethoxy)acetic acid

Biological Activity

[Description]:

Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Christopher Michael Semko, et al. C26-linked rapamycin analogs as mtor inhibitors. WO2019212991A1.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
316.4±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H7BrO3

[ Molecular Weight ]:
183.001

[ Flash Point ]:
145.2±20.9 °C

[ Exact Mass ]:
181.957855

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.493

Safety Information

[ Hazard Codes ]:
C

Related Compounds