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BOT-64

Names

[ CAS No. ]:
113760-29-5

[ Name ]:
BOT-64

[Synonym ]:
6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
1,3-Benzoxathiol-4(5H)-one,6,7-dihydro-6,6-dimethyl-2-(phenylimino)
2-phenylimino-4-oxo-4,5,6,7-tetrahydro-6,6-dimethyl-1,3-benzoxathiole
6,6-dimethyl-2-(phenylimino)-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one

Biological Activity

[Description]:

BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK
Research Areas >> Inflammation/Immunology

[Target]

IKKβ:1 μM (IC50)


[In Vivo]

BOT-64 (3-30 mg/kg) increases the survival rates of endotoxin LPS-shocked mice[1].

[References]

[1]. Kim BH, et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol. 2008 Apr;73(4):1309-18.

Chemical & Physical Properties

[ Density]:
1.27±0.1 g/cm3

[ Boiling Point ]:
402.1±48.0 °C

[ Molecular Formula ]:
C15H15NO2S

[ Molecular Weight ]:
273.35

[ Exact Mass ]:
273.08200

[ PSA ]:
70.81000

[ LogP ]:
3.72860

[ Storage condition ]:
20°C

Related Compounds