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PMEDAP

Names

[ CAS No. ]:
113852-41-8

[ Name ]:
PMEDAP

[Synonym ]:
{[2-(2,6-diamino-9h-purin-9-yl)ethoxy]methyl}phosphonic acid
N-(2-Phosphonomethoxyethyl)-2,6-diaminopurine
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
9-(2-phosphonomethoxyethyl)-2,6-diaminopurine
2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine
5-(3-Hydroxy-2-phosphonomethoxypropyladenine)
PME-DAP
Phosphonic acid,((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)
PMEDAP

Biological Activity

[Description]:

PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> CMV

[In Vivo]

PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV[1]. Animal Model: Three-week-old male NMRI mice[1] Dosage: 0.25 mg/kg, 1 mg/kg, 5 mg/kg Administration: IP; daily; starting on the day of infection and continuing for an additional four days Result: Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.

[References]

[1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446.

[2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047.

Chemical & Physical Properties

[ Density]:
2.03g/cm3

[ Boiling Point ]:
748.7ºC at 760mmHg

[ Molecular Formula ]:
C8H13N6O4P

[ Molecular Weight ]:
288.20

[ Flash Point ]:
406.6ºC

[ Exact Mass ]:
288.07400

[ PSA ]:
172.94000

[ Vapour Pressure ]:
1.51E-23mmHg at 25°C

[ Index of Refraction ]:
1.826

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds