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Cathepsin L inhibitor III

Names

[ CAS No. ]:
114014-15-2

[ Name ]:
Cathepsin L inhibitor III

[Synonym ]:
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Biological Activity

[Description]:

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

cathepsin L


[In Vitro]

Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) 在L929 细胞中导致呼肠孤病毒对病毒外衣壳蛋白的蛋白水解分解效率低下，并降低 病毒产量[1]。 Z-Phe-Tyr(tBu)-diazomethylketone 在 SARS-CoV-2 感染心肌细胞 (CM) 中将病毒检出率降低至处理对照组的10%[2]。

[References]

[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17.  

[2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H34N4O5

[ Molecular Weight ]:
542.63

[ Storage condition ]:
-15°C

Related Compounds