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N-(Iodoacetamido)-Doxorubicin

Names

[ CAS No. ]:
114390-30-6

[ Name ]:
N-(Iodoacetamido)-Doxorubicin

Biological Activity

[Description]:

N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₀INO₁₂

[ Molecular Weight ]:
711.45

Related Compounds