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Neuropeptide γ trifluoroacetate salt

Names

[ CAS No. ]:
114882-65-4

[ Name ]:
Neuropeptide γ trifluoroacetate salt

Biological Activity

[Description]:

γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release[1][2][3].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK2


[In Vitro]

γ-Neuropeptide 诱导完整雄性大鼠半垂体释放 LH 到培养基中[3]。 γ-Neuropeptide (1 nM-100 nM) 对雄性大鼠垂体前叶的 GH 释放没有影响[4]。

[In Vivo]

γ-Neuropeptide (rabbit) (0.4-2.0 nmol/kg，静脉注射) 可降低兔的血压[2]。 γ-Neuropeptide (0.5-10 nmol，i.c.v) 刺激雄性大鼠中血浆 LH 的增加[4]。

[References]

[1]. Kage R, et al. Neuropeptide-gamma: a peptide isolated from rabbit intestine that is derived from gamma-preprotachykinin. J Neurochem. 1988 May;50(5):1412-7.  

[2]. Yuan L, et al. Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit. Pulm Pharmacol Ther. 1998 Feb;11(1):31-9.  

[3]. Debeljuk L, et al. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides. 1999;20(2):285-99.  

[4]. Kalra PS, et al. Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action. Endocrinology. 1992 Sep;131(3):1195-201.  

[5]. Debeljuk L, et al. In vivo and in vitro effects of neuropeptide K and neuropeptide gamma on the release of growth hormone. Neuroreport. 1995 Dec 15;6(18):2457-60.  

Chemical & Physical Properties

[ Molecular Formula ]:
C99H158N34O29S

Related Compounds