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SR 16584

Names

[ CAS No. ]:
1150153-86-8

[ Name ]:
SR 16584

[Synonym ]:
1-[(3-exo)-9-Methyl-9-azabicyclo[3.3.1]non-3-yl]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 1,3-dihydro-1-[(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-

Biological Activity

[Description]:

SR 16584 is a selective antagonist of α3β4 nAChR with an IC50 of 10.2 μM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[References]

[1]. Zaveri N, et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem. 2010 Nov 25;53(22):8187-91.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
463.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H22N2O

[ Molecular Weight ]:
270.369

[ Flash Point ]:
211.7±21.1 °C

[ Exact Mass ]:
270.173218

[ PSA ]:
23.55000

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.596

Related Compounds