Tezacaftor(VX-661)

Names

[ Name ]:
Tezacaftor(VX-661)

[Synonym ]:
Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-
tezacaftorum
vx661
(r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
cs-1078
1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methyl-2-propanyl)-1H-indol-5-yl}cyclopropanecarboxamide
Tezacaftor

Biological Activity

[Description]:

VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Research Areas >> Cancer

[In Vitro]

In vitro, a combination of VX-661 and ivacaftor results in greater CFTR activity compared with VX-661 alone[2].

[References]

[1]. Treatment with VX-661 and Ivacaftor in a Phase 2 Study Resulted in Statistically Significant Improvements in Lung Function in People with Cystic Fibrosis Who Have Two Copies of the F508del Mutation. April 18, 2013

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
610.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₇F₃N₂O₆

[ Molecular Weight ]:
520.498

[ Flash Point ]:
323.2±31.5 °C

[ Exact Mass ]:
520.182129

[ PSA ]:
113.18000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
-20℃

Tezacaftor(VX-661)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds