Tolazamide

Names

[ Name ]:
Tolazamide

[Synonym ]:
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
Tolazamide
EINECS 214-588-3
MFCD00083504

Biological Activity

[Description]:

Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
289 °C772 mm Hg(lit.)

[ Melting Point ]:
171-173 °C(lit.)

[ Molecular Formula ]:
C₁₄H₂₁N₃O₃S

[ Molecular Weight ]:
311.40000

[ Flash Point ]:
100 °C

[ Exact Mass ]:
311.13000

[ PSA ]:
86.89000

[ LogP ]:
3.57440

[ Index of Refraction ]:
1.596

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT4400000

CHEMICAL NAME :: Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :: 1156-19-0

BEILSTEIN REFERENCE NO. :: 1323565

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H21-N3-O3-S

MOLECULAR WEIGHT :: 311.44

WISWESSER LINE NOTATION :: T7NTJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 256 mg/kg/3W-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 4 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YT4400000

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%