2',4',5,7-Tetrahydroxyisoflavone

Names

[ Name ]:
2',4',5,7-Tetrahydroxyisoflavone

[Synonym ]:
3-(2,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
2',4',5,7-Tetrahydroxyisoflavone
Isoflavone, 2',4',5,7-tetrahydroxy-
2'-HYDROXYGENISTEIN
4H-1-Benzopyran-4-one, 3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-
5,7,2',4'-Tetrahydroxy-isoflavone
3-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
MFCD00075967

Biological Activity

[Description]:

2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Ko HH, Weng JR, Tsao LT, Yen MH, Wang JP, Lin CN. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1011-4.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
619.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₀O₆

[ Molecular Weight ]:
286.24

[ Flash Point ]:
240.7±25.0 °C

[ Exact Mass ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.99

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.768

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%