3,5-Diiodothyropropionic Acid

Names

[ Name ]:
3,5-Diiodothyropropionic Acid

[Synonym ]:
DITPA
3-[4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-propionic acid
3,5-Ditpa
Dipro
DIPTA
3-[4-(4-Hydroxy-phenoxy)-3,5-dijod-phenyl]-propionsaeure
MFCD00045945
3-<4-(4-Hydroxy-phenoxy)-3,5-diiod-phenyl>-propionsaeure
3,5-Diiod-thyropropionsaeure
3,5-DIIODO-4-(4-HYDROXYPHENOXY)HYDROCINNAMIC ACID
3,5-Diiodothyropropionic acid

Biological Activity

[Description]:

3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Thyroid Hormone Receptor

[References]

[1]. Pennock GD, et al. Cardiac effects of 3,5-diiodothyropropionic acid, a thyroid hormone analog with inotropic selectivity. J Pharmacol Exp Ther. 1992 Oct;263(1):163-9.

Chemical & Physical Properties

[ Density]:
2.068g/cm3

[ Boiling Point ]:
535.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₂I₂O₄

[ Molecular Weight ]:
510.06200

[ Flash Point ]:
277.6ºC

[ Exact Mass ]:
509.88300

[ PSA ]:
66.76000

[ LogP ]:
4.41090

[ Vapour Pressure ]:
2.72E-12mmHg at 25°C

[ Index of Refraction ]:
1.708

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%