3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Names

[ Name ]:
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

[Synonym ]:
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
3-[5-(Aminomethyl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-2,6-piperidinedione hydrochloride (1:1)
MFCD31794744

Biological Activity

[Description]:

Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆ClN₃O₃

[ Molecular Weight ]:
309.748

[ Exact Mass ]:
309.088013

Safety Information

[ Hazard Codes ]:
Xi