succinylsulfathiazole

Names

[ CAS No. ]:
116-43-8

[ Name ]:
succinylsulfathiazole

[Synonym ]:
EINECS 204-141-0
Succinanilic acid, 4'-(2-thiazolylsulfamoyl)-
MFCD00022437
succinylsulfathiazole
4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide Hydrate
Succinylsulfathiazole Hydrate
Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]-
4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide
N1-(2-THIAZOLYL)-N4-SUCCINOYLSULFANILAMIDE
N4-Succinyl-N-(2-thiazolyl)sulfanilamide Hydrate
N4-Succinyl-N-(2-thiazolyl)sulfanilamide
4-oxo-4-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]butanoic acid
p-2-Thiazolylsulfamoylsuccinanilic acid
4-Oxo-4-{[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]amino}butanoic acid
4-oxo-4-{4-[(1,3-thiazol-2-ylamino)sulfonyl]anilino}butanoic acid

Biological Activity

[Description]:

Succinylsulfathiazole is a sulfonamide, it is an ultra long acting drug.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
187 - 193ºC

[ Molecular Formula ]:
C₁₃H₁₃N₃O₅S₂

[ Molecular Weight ]:
355.389

[ Exact Mass ]:
355.029663

[ PSA ]:
162.08000

[ LogP ]:
0.68

[ Index of Refraction ]:
1.679

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM4767000

CHEMICAL NAME :: Succinanilic acid, 4'-(2-thiazolylsulfamoyl)-

CAS REGISTRY NUMBER :: 116-43-8

BEILSTEIN REFERENCE NO. :: 0349989

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H13-N3-O5-S2

MOLECULAR WEIGHT :: 355.41

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DMV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,231,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 7,151,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81640 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 230 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S22-S36/37-S45

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
WM4767000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.

Toxicol. Lett. 215(3) , 214-8, (2012)

In most mammalian species, arsenic biotransformation occurs primarily by biomethylation and reduction reactions, with dimethylarsinic acid being the predominant metabolite excreted in the urine. Methy...

Prediction of drug intestinal absorption by new linear and non-linear QSPR.

Eur. J. Med. Chem. 46 , 218-28, (2011)

In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at...

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

J. Neurosci. 28 , 7219-7230, (2008)

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...