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Gemcitabine Monophosphate Formate Salt

Names

[ CAS No. ]:
116371-67-6

[ Name ]:
Gemcitabine Monophosphate Formate Salt

[Synonym ]:
gemcitabine 5'-monophosphate
2'-deoxy-2',2'-difluorocytidine 5-monophosphate
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Formate
Gemcitabine Monophosphate Formate Salt
Gemcitabine monophosphate

Biological Activity

[Description]:

Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate shows synergistic anti-cancer effects[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69.

[2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611.

Chemical & Physical Properties

[ Density]:
2.09

[ Boiling Point ]:
618.3ºC at 760 mmHg

[ Melting Point ]:
151-153 °C

[ Molecular Formula ]:
C9H12F2N3O7P

[ Molecular Weight ]:
343.17800

[ Flash Point ]:
327.736ºC

[ Exact Mass ]:
343.03800

[ PSA ]:
166.94000

[ Index of Refraction ]:
1.681

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds