Nexopamil racemate

Names

[ CAS No. ]:
116759-35-4

[ Name ]:
Nexopamil racemate

[Synonym ]:
Benzeneacetonitrile, α-[3-(hexylmethylamino)propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-
5-[Hexyl(methyl)amino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile

Biological Activity

[Description]:

Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease

[Target]

Ca2+/5-HT2[1]


[In Vitro]

Serotonin-induced platelet aggregation in dog platelet-rich plasma (PRP) in vitro is most potently inhibited by Nexopamil (IC50 81 nM) [1].

[In Vivo]

Nexopamil (0.05 mg/kg) completely abolishes cyclic flow reductions (CFRs) during the first 30 min after application without significantly altering hemodynamics[1].

[References]

[1]. Kirchengast M, et al. Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.


[Related Small Molecules]

Neomycin sulfate | Nifedipine | Harmine | Acetylcholine chloride | Pimavanserin | Ionomycin | (S)-(-)-Bay K 8644 | Nimodipine | Mibefradil dihydrochloride | Serotonin hydrochloride | Sodium Ferulate | Levetiracetam | Thioridazine hydrochloride | Brexpiprazole | CDN 1163

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
514.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H40N2O3

[ Molecular Weight ]:
404.586

[ Flash Point ]:
265.1±30.1 °C

[ Exact Mass ]:
404.303894

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.492

Related Compounds