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L-LYSYL-D-PROLYL-L-THREONINE

Names

[ CAS No. ]:
117027-34-6

[ Name ]:
L-LYSYL-D-PROLYL-L-THREONINE

[Synonym ]:
l-lysyl-d-prolyl-l-threonine
l-lys-d-pro-l-thr
lys-d-pro-thr
interleukin 1b antagonist
[D-Pro194]-IL-1 b (193-195) (human)

Biological Activity

[Description]:

Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Metabolic Disease

[Target]

IL-1


[In Vivo]

Lys-D-Pro-Thr (10 mg/kg; 腹腔给药; 持续 4 天) 抑制 fMLP (HY-P0224) 和 MMK-1 (HY-P1117) 对依托泊苷 (HY-13629) 诱导脱发的保护作用[1]。 Animal Model: 11-d-old rats[1] Dosage: 10 mg/kg Administration: IP; for 4 days Result: Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.

[References]

[1]. Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202.  

[2]. Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11.  

Chemical & Physical Properties

[ Density]:
1.288g/cm3

[ Boiling Point ]:
691.3ºC at 760mmHg

[ Molecular Formula ]:
C15H28N4O5

[ Molecular Weight ]:
344.41

[ Flash Point ]:
371.9ºC

[ Exact Mass ]:
344.20600

[ PSA ]:
158.98000

[ LogP ]:
0.11330

[ Vapour Pressure ]:
4.12E-22mmHg at 25°C

[ Index of Refraction ]:
1.56

Safety Information

[ Safety Phrases ]:
22-24/25

Related Compounds