HO-3867

HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity.

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

STAT3

HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation[1]. BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP[2]. HO-3867 shows good antitumor activity at the concentration of 2 μmol/L in PANC-1 and BXPC-3 cells. Importantly, it is also found that HO-3867 treatment significantly induced reactive oxygen species (ROS) production in human pancreatic cancer cell lines, inducing PANC-1 and BXPC-3 cells[3].

[1]. Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27.

[2]. Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13(9):766-75

[3]. Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28(4):392-400.

Tyrphostin B42 (AG-490) | Stattic | AS1517499 | S3I-201 | Cryptotanshinone | Napabucasin | Homoharringtonine | STAT5-IN-1 | WP1066 | Niclosamide | BP-1-102 | Scutellarin | SH-4-54 | Artesunate | Cucurbitacin I