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ORL1 antagonist 1

Names

[ CAS No. ]:
1174985-59-1

[ Name ]:
ORL1 antagonist 1

Biological Activity

[Description]:

ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

IC50: 61 nM (ORL1)[1]

[In Vitro]

ORL1 antagonist 1 is compound 17[1].

[References]

[1]. Kobayashi K, et al. Discovery of novel arylpyrazole series as potent and selective opioid receptor-like 1 (ORL1) antagonists. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3627-31.

[Related Small Molecules]

PZM-21 | Loperamide hydrochloride | Oliceridine hydrochloride | ADL5859 HCl | JDTic (dihydrochloride) | Naltrindole hydrochloride | LY-2456302 | JTC-801 | Matrine | Met-Enkephalin acetate salt | Cebranopadol | Leu-Enkephalin | DAMGO | Sinomenine HCl | SR17018

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂ClN₅

[ Molecular Weight ]:
367.88

Related Compounds