1,7-Bis-Boc-1,4,7-triazaheptane

Names

[ Name ]:
1,7-Bis-Boc-1,4,7-triazaheptane

[Synonym ]:
1,7-Bis-Boc-1,4,7-triazaheptane
Bis(2-Methyl-2-Propanyl) (Iminodi-2,1-Ethanediyl)Biscarbamate
Di-tert-butyl (azanediylbis(ethane-2,1-diyl))dicarbamate

Biological Activity

[Description]:

1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1g/cm3

[ Boiling Point ]:
440.5±30.0°C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₉N₃O₄

[ Molecular Weight ]:
303.39800

[ Flash Point ]:
220.2±24.6°C

[ Exact Mass ]:
303.21600

[ PSA ]:
88.69000

[ LogP ]:
2.79810

[ Index of Refraction ]:
1.466

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%