Pseudouridine 5'-triphosphate

Names

[ Name ]:
Pseudouridine 5'-triphosphate

[Synonym ]:
Pseudouridine 5`-Triphosphate

Biological Activity

[Description]:

pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-Scale Chemical Synthesis of Base-Modified Ribonucleoside-5'-O-Triphosphates. Curr Protoc Nucleic Acid Chem. 2016;67:13.15.1-13.15.10.

[2]. Borchardt EK, Martinez NM, Gilbert WV. Regulation and Function of RNA Pseudouridylation in Human Cells. Annu Rev Genet. 2020;54:309-336.

[3]. Anderson BR, Muramatsu H, Nallagatla SR, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 2010;38(17):5884-5892.