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SMANT hydrochloride

Names

[ CAS No. ]:
1177600-74-6

[ Name ]:
SMANT hydrochloride

Biological Activity

[Description]:

SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo
Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[Target]

Smo, SmoM2[1]


[In Vitro]

SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC50: 1.1 μM)[1]. SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay[1]. SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1+/− neonates) induced by Shh[1].

[References]

[1]. Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H24BrClN2O

[ Molecular Weight ]:
375.73200

[ Exact Mass ]:
374.07600

[ PSA ]:
32.34000

[ LogP ]:
4.56850

Safety Information

[ Symbol ]:

GHS09

[ Hazard Statements ]:
H411

[ Precautionary Statements ]:
P273-P391-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds