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Ponezumab

Names

[ CAS No. ]:
1178862-65-1

[ Name ]:
Ponezumab

Biological Activity

[Description]:

Ponezumab (PF-04360365) is a humanised anti-amyloid IgG2 monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Research Areas >> Neurological Disease

[Target]

IgG2[1].


[References]

[1]. Nicholas T, et al. Preliminary population pharmacokinetic modeling of PF-04360365, a humanized anti-amyloid monoclonal antibody, in patients with mild-to-moderate Alzheimer's disease[J]. Alzheimer's and Dementia, 2009, 5(4): P253.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds