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GLYX 13 TFA

Names

[ CAS No. ]:
117928-94-6

[ Name ]:
GLYX 13 TFA

[Synonym ]:
L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate
Thr-Pro-Pro-Thr-NH2 trifluoroacetate TPPT-amide trifluoroacetate
(2S)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
Rapastinel
GLYX 13

Biological Activity

[Description]:

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDARapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Peptides

[References]

[1]. Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.


[Related Small Molecules]

(+)-MK 801 Maleate | CNQX | N-Methyl-D-aspartic acid | ifenprodil tartrate | D-AP5(mM/ml) | DNQX | Ro 25-6981 maleate | Flupirtine maleate | Mibampator | CX546 | Naspm | Talampanel | Centrophenoxine hydrochloride | 24-Hydroxycholesterol

Chemical & Physical Properties

[ Molecular Formula ]:
C18H31N5O6

[ Molecular Weight ]:
413.46900

[ Exact Mass ]:
413.22700

[ PSA ]:
179.29000

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Related Compounds