Fodipir

Names

[ CAS No. ]:
118248-91-2

[ Name ]:
Fodipir

[Synonym ]:
N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid-5,5'-bis(phosphate) dihydrate
N,N'-di-p-toluoyl-p-benzoquinone diimine
Benzamide,N,N'-2,5-cyclohexadiene-1,4-diylidenebis[4-methyl
Fodipir

Biological Activity

[Description]:

Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. Fodipir (Dp-dp; Dipyridoxyl diphosphate; 100 μM) shows the best cytopretective effect on 7β-OH-mediated cell death after treatment for 8 h. Fodipir also reduces 7β-OH-induced cellular ROS production and lysosomal membrane permeabilization (LMP)[1].

[References]

[1]. Laskar A, et al. Fodipir and its dephosphorylated derivative dipyridoxyl ethyldiamine are involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. Pharmacology. 2013;92(3-4):182-6.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.657g/cm3

[ Boiling Point ]:
1049.1ºC at 760mmHg

[ Molecular Formula ]:
C22H32N4O14P2

[ Molecular Weight ]:
638.46

[ Flash Point ]:
588.3ºC

[ PSA ]:
309.69000

[ LogP ]:
0.13230

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.655