ELOVL6-IN-1
Names
[ CAS No. ]:
1185736-98-4
[ Name ]:
ELOVL6-IN-1
Biological Activity
[Description]:
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
[Related Catalog]:
[Target]
IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1]
[In Vitro]
ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].
[In Vivo]
ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1]. ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1]. ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1]. Animal Model: C57BL/6J mice Dosage: 10 mg/kg Administration: P.o. Result: Displayed appreciable plasma and liver exposure. Animal Model: C57BL/6J mice Dosage: 10 and 30 mg/kg Administration: P.o. Result: Reduced the elongation index of the liver lipids. Animal Model: C57BL/6J mice Dosage: 100 mg/kg Administration: P.o. Result: Reduced the elongation index of the total fatty acids of the liver.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C27H24F3N3O3
[ Molecular Weight ]:
495.49