DDO-02005 free base

Names

[ Name ]:
DDO-02005 free base

Biological Activity

[Description]:

DDO-02005 (free base) is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 (free base) has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.72 μM (Kv1.5 potassium channel)[1]

[References]

[1]. Zhao L, et al. Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors. J Enzyme Inhib Med Chem. 2022;37(1):462-471.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅N₃O₂

[ Molecular Weight ]:
351.44

DDO-02005 free base

Names

Biological Activity

Chemical & Physical Properties

Related Compounds