4-Bromobutylphosphonic acid

Names

[ Name ]:
4-Bromobutylphosphonic acid

[Synonym ]:
.(4-bromo-butyl)-phosphonic acid
.4-Brom-butanphosphonsaeure
4-bromobutylphosphonic acid
.4-Brom-butan-phosphonsaeure-(1)

Biological Activity

[Description]:

4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
129 °C

[ Molecular Formula ]:
C₄H₁₀BrO₃P

[ Molecular Weight ]:
216.99800

[ Exact Mass ]:
215.95500

[ PSA ]:
67.34000

[ LogP ]:
1.33920

4-Bromobutylphosphonic acid

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds