Bisindolylmaleimide IV

Names

[ CAS No. ]:
119139-23-0

[ Name ]:
Bisindolylmaleimide IV

[Synonym ]:
MFCD00236432
3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione
2,3-bis-(1h-indol-3-yl)-maleimide
3,4-Bis(3-indolyl)maleimide
3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-

Biological Activity

[Description]:

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Infection

Signaling Pathways >> TGF-beta/Smad >> PKC

Signaling Pathways >> Anti-infection >> CMV

[Target]

PKC:0.1-0.55 μM (IC50)

HCMV:0.2 μM (IC50)

[In Vitro]

Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1].

[References]

[1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.

[2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
690.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₃N₃O₂

[ Molecular Weight ]:
327.336

[ Flash Point ]:
371.2±31.5 °C

[ Exact Mass ]:
327.100769

[ PSA ]:
77.75000

[ LogP ]:
3.21

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.811

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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