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Burixafor hydrobromide (TG-0054 hydrobromide)

Names

[ CAS No. ]:
1191450-19-7

[ Name ]:
Burixafor hydrobromide (TG-0054 hydrobromide)

Biological Activity

[Description]:

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization[1]. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> CXCR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4


[References]

[1]. Shelke NB, et al. Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases. Drug Deliv Transl Res. 2011 Feb;1(1):76-90.

[2]. Hsu WT, et al. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H51N8O3P.xHBr

[ Molecular Weight ]:
769.01

[ Storage condition ]:
2-8℃

Related Compounds