Bis-PEG6-acid

Names

[ CAS No. ]:
119189-70-7

[ Name ]:
Bis-PEG6-acid

[Synonym ]:
4,7,10,13,16,19-Hexaoxadocosane-1,22-dioic acid
MFCD20926399

Biological Activity

[Description]:

Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
543.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₀O₁₀

[ Molecular Weight ]:
382.403

[ Flash Point ]:
187.7±23.6 °C

[ Exact Mass ]:
382.183899

[ LogP ]:
-2.26

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.473

Bis-PEG6-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds