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Diclofenac Epolamine

Names

[ CAS No. ]:
119623-66-4

[ Name ]:
Diclofenac Epolamine

[Synonym ]:
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)methyl]-, compd. with 1-pyrrolidineethanol (1:1)
2-[2-(2,6-dichloroanilino)phenyl]acetic acid,2-pyrrolidin-1-ylethanol
UNII-X5F8EKL9ZG
Diclofenac hydroxyethylpyrrolidine
Diclofenac-N-(2-hydroxyethyl) pyrrolidine
[2-(2,6-Dichlorobenzyl)phenyl]acetic acid - 2-(1-pyrrolidinyl)ethanol (1:1)
DHEP plaster
Flector
Flector (TN)
DHEP

Biological Activity

[Description]:

Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID)[1]. Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Del Río-Sancho S, et al. Topical delivery of diclofenac into and across equine skin from a novel liquid diclofenac epolamine formulation. J Vet Pharmacol Ther. 2016 Dec. 39(6):578-583.  

[2]. Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 2013 Sep 10;453(2):569-78.  

Chemical & Physical Properties

[ Boiling Point ]:
412ºC at 760mmHg

[ Molecular Formula ]:
C20H24Cl2N2O3

[ Molecular Weight ]:
411.32

[ Flash Point ]:
203ºC

[ PSA ]:
60.77000

[ LogP ]:
4.22370

[ Vapour Pressure ]:
1.59E-07mmHg at 25°C

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
N

Related Compounds