<Suppliers Price>

ST-1006 Maleate

Names

[ CAS No. ]:
1196994-12-3

[ Name ]:
ST-1006 Maleate

Biological Activity

[Description]:

ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vitro]

ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils[2]. ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].

[In Vivo]

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect[1]. Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.

[References]

[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.  

[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H28Cl2N6O8

[ Molecular Weight ]:
599.42

Related Compounds