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AP26113

Names

[ CAS No. ]:
1197958-12-5

[ Name ]:
AP26113

[Synonym ]:
2,4-Pyrimidinediamine, 5-chloro-N-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N-[2-(dimethylphosphinyl)phenyl]-
5-Chloro-N-{4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl}-N-[2-(dimethylphosphoryl)phenyl]-2,4-pyrimidinediamine
AP26113
Brigatinib
ALK-IN-1

Biological Activity

[Description]:

ALK-IN-1 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Research Areas >> Cancer

[References]

[1]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1

[2]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1


[Related Small Molecules]

Brigatinib | lorlatinib | Alectinib (CH5424802) | Entrectinib | TAE684(NVP-TAE684) | AZD-3463 | Repotrectinib | Ensartinib | K 02288 | ASP3026 | CEP-37440 | GSK1838705A | Belizatinib | X-396 hydrochloride

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
737.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H34ClN6O2P

[ Molecular Weight ]:
529.014

[ Flash Point ]:
399.9±35.7 °C

[ Exact Mass ]:
528.216919

[ PSA ]:
95.66000

[ LogP ]:
1.10

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
-20°C

Related Compounds