9,10-dihydroxystearic acid

Names

[ CAS No. ]:
120-87-6

[ Name ]:
9,10-dihydroxystearic acid

[Synonym ]:
9 10-DIHYDROXYOCTADECANOIC ACID
Octadecanoic acid, 9,10-dihydroxy-
9,10-DIHYDROXYSTEARIC ACID
9,10-Dihydroxyoctadecanoic acid
9,10-Dihydroxystearate
EINECS 204-432-2

Biological Activity

[Description]:

9,10-Dihydroxystearic acid is an oxidation product of oleic acid. 9,10-Dihydroxystearic acid can improve glucose tolerance and insulin sensitivity in KKAy mice[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

5-20 μmol/L 9,10-Dihydroxystearic acid (DHSA) does not activate PPAR-γ in CV-1 cells but 50-100 μmol/L DHSA activates PPAR-γ in a dose-dependent way. 9,10-Dihydroxystearic acid does not activate PPAR-α in CV-1 cells[1].

[In Vivo]

9,10-Dihydroxystearic acid (DHSA; fed with high fat diet containing 4% DHSA; for 5-6 weeks) treatment improves glucose tolerance and insulin sensitivity in KKAy mice[1].

[References]

[1]. Xiaoming Yu, et al. Effects of 9,10-dihydroxysteatic acid on glucose metabolism in KKAy mice. Wei Sheng Yan Jiu. 2010 Jul;39(4):423-5.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
481.6±25.0 °C at 760 mmHg

[ Melting Point ]:
92-94ºC

[ Molecular Formula ]:
C₁₈H₃₆O₄

[ Molecular Weight ]:
316.476

[ Flash Point ]:
259.2±19.7 °C

[ Exact Mass ]:
316.261353

[ PSA ]:
77.76000

[ LogP ]:
4.34

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.481

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2918199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%