CAY10621(SKI 5C)

Names

[ CAS No. ]:
120005-55-2

[ Name ]:
CAY10621(SKI 5C)

[Synonym ]:
2-Methyl-2-propanyl (4S)-4-(2-hexadecynoyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-, 1,1-dimethylethyl ester, (4S)-
z-n-e-boc-l-lysine amide

Biological Activity

[Description]:

CAY10621 (SKI 5C; compound 5c) is a specific sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> SPHK

[References]

[1]. Lingkai Wong, et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
519.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₅NO₄

[ Molecular Weight ]:
435.640

[ Flash Point ]:
267.7±32.9 °C

[ Exact Mass ]:
435.334869

[ PSA ]:
55.84000

[ LogP ]:
8.67

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.478

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.

Liver Int. 32(2) , 331-8, (2012)

Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, lit...