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L-Azidohomoalanine

Names

[ CAS No. ]:
120042-14-0

[ Name ]:
L-Azidohomoalanine

[Synonym ]:
4-Azido-homoalanine
2(S)-Amino-4-azido-butanoic Acid
azidohomoalanine
Butanoic acid,2-amino-4-azido-,(2S)
AmbotzHAA5730
L-Azidohomoalanine
4-Azido-L-2-aminobutyrate
azodohomoalanine
L-4-azido-2-aminobutanoic acid

Biological Activity

[Description]:

L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Melting Point ]:
220-223ºC

[ Molecular Formula ]:
C4H8N4O2

[ Molecular Weight ]:
144.13200

[ Exact Mass ]:
144.06500

[ PSA ]:
113.07000

[ LogP ]:
0.25176

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds