Clopidogrel bisulfate

Names

[ CAS No. ]:
120202-66-6

[ Name ]:
Clopidogrel bisulfate

[Synonym ]:
Methyl (S)-(+)-2-(2-Chlorophenyl)-2-[6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]acetate Sulfate
MFCD00876395
Plavix
Clopidogrel sulfate
Clopidogrel Hydrogen sulfate
Methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate sulfate
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate sulfate (1:1)
Clopidogrel bisulfate
(S)-(+)-Clopidogrel Sulfate
(2S)-(2-chlorophényl)(6,7-dihydrothiéno[3,2-c]pyridin-5(4H)-yl)éthanoate de méthyle sulfate
Clopidogrel Hydrogensulfate
Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-, sulfate (1:1)
(+)-Clopidogrel hydrogen sulfate
Clopidogrel bisulphate
(S)-(+)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate bisulfate
Methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate (1:1)
a-(S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic Acid Methyl Ester Sulfate (1:1)
Methyl aS-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate Sulfate (1:1)
Methyl-(2S)-(2-chlorphenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoatsulfat
Clopidogrel
(S)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogensulfate
S-(+)-Clopidogrel Hydrogen Sulfate
Clopidogrel (hydrogen sulfate)

Biological Activity

[Description]:

Clopidogrel is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

Research Areas >> Cardiovascular Disease

[References]

[1]. Geiger, J., et al., Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel. Arterioscler Thromb Vasc Biol, 1999. 19(8): p. 2007-11.

[2]. Roald, H.E., et al., Clopidogrel--a platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions. Thromb Haemost, 1994. 71(5): p. 655-62.

[3]. Ramadan, R., et al., Effects of Clopidogrel Therapy on Oxidative Stress, Inflammation, Vascular Function and Progenitor Cells in Stable Coronary Artery Disease. J Cardiovasc Pharmacol, 2013.

[Related Small Molecules]

Suramin sodium | MRS 2578 | Diquafosol Tetrasodium | Prasugrel | BPTU | AZD 1283 | TAK-024

Chemical & Physical Properties

[ Boiling Point ]:
423.7ºC at 760 mmHg

[ Melting Point ]:
184ºC

[ Molecular Formula ]:
C₁₆H₁₈ClNO₆S₂

[ Molecular Weight ]:
419.900

[ Flash Point ]:
210ºC

[ Exact Mass ]:
419.026398

[ PSA ]:
140.76000

[ LogP ]:
3.96550

[ Appearance of Characters ]:
solid | white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ~26 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
UN 1759

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000

Articles

Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.

J. Chromatogr. A. 1418 , 140-9, (2015)

The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of...

RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

J. Clin. Invest. 125(4) , 1419-32, (2015)

The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of t...

Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases.

Eur. J. Pharm. Sci. 78 , 47-53, (2015)

Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly expressed in the human l...