salvinolone

Names

[ CAS No. ]:
120278-22-0

[ Name ]:
salvinolone

[Synonym ]:
5,6-Dihydroxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a-tetrahydro-1H-phenanthren-9-one

Biological Activity

[Description]:

Salvinolone is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Salvinolone shows cytotoxic activity with an IC50 of 47.6 μM against the HL-60 tumor cell line for 72 h[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Mingfeng Xu, et al. Bioactive diterpenes from Clerodendrum kaichianum. Nat Prod Commun. 2011 Jan;6(1):3-5.

[2]. EnriqueAlvarez-Manzaneda, et al. First synthesis of picealactone C. A new route toward taxodione-related terpenoids from abietic acid. Tetrahedron Letters, Volume 48, Issue 6, 5 February 2007, Pages 989-992.

Chemical & Physical Properties

[ Density]:
1.18±0.1 g/cm3

[ Boiling Point ]:
498.8±45.0 °C at 760 mmHg

[ Melting Point ]:
253-254 °C

[ Molecular Formula ]:
C₂₀H₂₆O₃

[ Molecular Weight ]:
314.41900

[ Exact Mass ]:
314.18800

[ PSA ]:
57.53000

[ LogP ]:
4.81170