Biotin-PFP ester

Names

[ CAS No. ]:
120550-35-8

[ Name ]:
Biotin-PFP ester

[Synonym ]:
biotin-pentafluoro-phenyl ester
Pentafluorophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
D-biotin pentafluorophenyl ester
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2,3,4,5,6-pentafluorophenyl ester, (3aS,4S,6aR)-
(+)-Biotin-PFP-ester
biotinylpentafluorophenyl ester
Perfluorophenyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
PFP-Biotin

Biological Activity

[Description]:

Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
555.3±50.0 °C at 760 mmHg

[ Melting Point ]:
190.0 to 194.0 °C

[ Molecular Formula ]:
C₁₆H₁₅F₅N₂O₃S

[ Molecular Weight ]:
410.359

[ Flash Point ]:
289.6±30.1 °C

[ Exact Mass ]:
410.072357

[ PSA ]:
92.73000

[ LogP ]:
2.85

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Storage condition ]:
2-8°C

Biotin-PFP ester

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds