AV-105

Names

[ CAS No. ]:
1205550-99-7

[ Name ]:
AV-105

[Synonym ]:
.(E)-2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
AV-105

Biological Activity

[Description]:

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

The AV-105 synthesis method utilizes a primary tosylate instead of a primary mesylate as an active leaving group. Use of the tosylate precursor for radiofluorination is beneficial, at least for the reason that the tosylate generated during the radiofluorination reaction is readily removed by chromatographic means from the 18F-radiolabeled imaging product[1].

[References]

[1]. Tyler Benedum, et al. Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof. WO2010078370A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₄₀N₂O₈S

[ Molecular Weight ]:
612.73400

[ Exact Mass ]:
612.25100

[ PSA ]:
121.87000

[ LogP ]:
6.83000

AV-105

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds